2 edition of Drug tolerance, dependence, and abuse found in the catalog.
Drug tolerance, dependence, and abuse
Leo E. Hollister
Bibliography: p. 54-58.
|Statement||Leo E. Hollister.|
|LC Classifications||RM316 .H65 1985|
|The Physical Object|
|Pagination||58 p. :|
|Number of Pages||58|
|LC Control Number||86190233|
A phenomenon in which the tolerance that results from the chronic use of one drug induces a tolerance effect with regard to a second drug that has not been used before. Cross-dependence A phenomenon in which one drug can be used to reduce the withdrawal symptoms following the discontinuance of . Tolerance vs. Dependence vs. Addiction Long-term use of prescription opioids, even as prescribed by a doctor, can cause some people to develop a tolerance, which means that they need higher and/or more frequent doses of the drug to get the desired effects.. Drug dependence occurs with repeated use, causing the neurons to adapt so they only function normally in the presence of the drug.
Tolerance and dependence are also not uniquely found in alcoholism. Tolerance and dependence are naturally occurring “adaptations” found in the use of many drugs, either those to which man becomes addicted or those that benefit man as medications for diseases and other behaviors, especially those that are associated with other addictions. 1, 2Author: Norman S. Miller, Mark S. Gold. Like many drugs persons taking narcotics can develop a tolerance as well as psychological and physical dependence. With this dependence, users must increase the dosage to gain the same effect. Some signs of narcotic abuse are analgesia, sedation, shallow breathing, slurred speech, and or/confusion.
Physical dependence, however, refers to the issues of physiologic dependence, establishment of tolerance, and evidence of an abstinence syndrome or withdrawal upon cessation of alcohol or other drug use. Tolerance, dependence, and withdrawal develop differently depending on the particular substance (HHS/SAMHSA, ). Drugs, Crime, and Justice is an engaging, yet comprehensive, analysis of the interrelationships among drug use/abuse, crime, and first four chapters introduce readers to the interrelationships between drugs and crime, while the second later chapters provide readers with an overview of historical and contemporary policies, as well as a comprehensive review of research on policing.
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Pratt JA. Psychotropic drug tolerance and dependence: common underlying mechanisms. In: Pratt E, ed. The Biological Bases of Drug Tolerance and Dependence. London: Academic Press, Harcourt Brace Jovanovich, Brown RL.
Identification and office management of alcohol and drug disorders. In: Fleming MF, Barry KL, eds. Addictive Disorders. Drug dependence is “a state of psychic or physical dependence, or both, on a drug, arising in a person following administration of that drug on a periodic or continuous basis.” 1 Drug abuse, on the other hand, refers to the perception that recreational use of a substance is harmful, regardless of whether the substance is taken continuously.
The effect of a drug is proportional to its concentration at its site of action. The response to a drug will depend upon tolerance and previous exposure to the drug and other compounds that might create sensitivity dependence the drug.
Continued use of certain and abuse book may. Get this from a library. Drug tolerance, dependence, and abuse. [Leo E Hollister]. Psychological dependence is the subjective feeling that the user needs the drug to maintain a feeling of well-being; physical dependence is characterized by tolerance (the need for increasingly larger doses in order to achieve the initial effect) and withdrawal symptoms when the user is abstinent.
Tolerance is a state of adaptation in which exposure to a drug induces changes that result in a diminution (i.e., diminishing or lessening) of one or more of the drug's effects over time.
That said, most pain medicine and addiction specialists concur that chronic pain patients treated longterm with opioid drugs usually do develop physical. Betsy Ferguson, David Glenn Smith, in The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment, Immune Response Variation as a Variable in Drug Safety Testing.
Variable immune sensitivities among individuals can also contribute to disparate drug tolerance measures in macaques. In extreme cases, super cytokine response can lead to organ failure or fatality .
Drug tolerance is indicative of drug use but is not necessarily associated with drug dependence or addiction. The process of tolerance development is reversible (e.g., through a drug holiday) and can involve both physiological factors and psychological factors.
Substance dependence, also known as drug dependence, is an adaptive state that develops from repeated drug administration, and which results in withdrawal upon cessation of drug use. A drug addiction, a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences.
An addictive drug is a drug which is both rewarding and reinforcing. From a clinical standpoint, withdrawal can be one of the most powerful factors driving dependence and addictive behaviors.
This seems particularly true for opioids, alcohol, benzodiazepines, nicotine, and to a lesser extent stimulants such as hallucinogens, cannabinoids, or inhalants, withdrawal symptoms seem of more limited importance.
The objective of the teaching packet is to inform students (high school) how 3 drugs of abuse (cocaine, opiates, marijuana) actually work in the brain. The packet is arranged in 3 sections. The first section introduces the brain and presents some basic neurobiology, the second introduces the reward pathway and the third presents the mechanism.
Drug dependence occurs when you need one or more drugs to function. The American Psychiatric Association (APA) used to distinguish between dependence and : Marissa Selner. Zero tolerance: Families and drug addiction. What position should your family take when it comes to drug use, abuse, and addiction.
Here, we review why and how a zero tolerance for drug abuse can help you and your family. Then, we offer eight (8) crucial points for creating a safe environment when an addict is living at home. els of drug-seeking behavior, that have, for example, yielded objective measures of initiation and repeated administration of drugs, thereby providing the scientific foundation for assessments of "abuse liability" (i.e., the potential for abuse) of specific drugs (see Chapter 2).This information is an essential predicate for informed regulatory decisions under the Food, Drug and Cosmetic Act.
Neuroscience of psychoactive substance use and dependenceis written for individuals with more than a basic knowledge of the field, including scientists from a variety of disciplines.
The book should be of interest to health care workers, clinicians, social workers, university students, science teachers and policy makers. ISBN 92 4 8. COVID Resources.
Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.
The terms "addiction," "abuse," and "dependence" have traditionally been used in regard to people with substance use disorders. However, those terms are all too loosely and variably defined to be very useful and also are often used judgmentally.
Thus, doctors now prefer to use the more comprehensive and less negative term "substance use disorder.". Dependence on marijuana happens when users build up a tolerance for the substance and need more and more of it to experience the same effect.
A study [ 4 ] discovered that people who used marijuana had fewer cannabinoid receptors in their brain for endogenous cannabinoids.
Without physiologic dependence (no evidence of tolerance or withdrawal). In addition, remission categories are classified into four subtypes: (1) full, (2) early partial, (3) sustained, and (4) sustained partial; on the basis of whether any of the criteria for abuse or.
The APA ditched both “substance abuse” and “substance dependence” in favor of “substance use disorder.” Substance use disorder is now the medical term for addiction. Previously, abuse was a mild form of addiction, and dependence was a moderate or severe form of addiction.
So whether you are someone that thinks they may be having an issue with drug addiction or alcohol abuse or you are a family member that suspects a loved one is suffering from substance abuse, here are five signs and symptoms of alcohol and/or drug dependence.
1) Increased tolerance. Over time, if the person may be in danger of having or. DRUG USE AND ABUSE takes an interdisciplinary approach in its coverage of current drug issues. It weaves psychological, historical, cultural, social, biological, and medical perspectives -- emphasizing the idea that a drug’s effects depend not only on its properties, but also on the biological and psychological characteristics of its user.Recognizing the Signs of Substance Abuse.
Drug use affects people from all walks of life and all socioeconomic statuses. Whatever the reason a person starts taking drugs, whether recreationally or as prescribed, tolerance, patterns of increased use, physical dependence and, ultimately, addiction may develop—sometimes before the user even realizes it.